Publications

2023

Sex-related external factors influence pulmonary vascular angiogenesis in a sex-dependent manner.

Hayward-Piatkovskyi B, Gonyea CR, Pyle SC, Lingappan K, Gleghorn JP

doi: 10.1152/ajpheart.00552.2022

Published online 2022 Nov 11.

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The Need to Address Sex as a Biological Variable in Neonatal Clinical Studies.

Lingappan K, Alur P, Eichenwald E

doi: 10.1016/j.jpeds.2022.11.021

Published online 2022 Nov 30.

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Lung biopsy in infants with severe bronchopulmonary dysplasia.

Callaway DA, Wang Y, Lingappan K, Pogoriler JE, Laje P, Nilan K, Kirpalani H, Zhang H

doi: 10.1002/ppul.26433

Published online 2023 May 3.

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Videolaryngoscopy versus direct laryngoscopy for tracheal intubation in neonates.

Lingappan K, Neveln N, Arnold JL, Fernandes CJ, Pammi M

doi: 10.1002/14651858.CD009975.pub4

Published online 2023 May 12.

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Loss of cytochrome P450 (CYP)1B1 mitigates hyperoxia response in adult mouse lung by reprogramming metabolism and translation.

Grimm SL, Stading RE, Robertson MJ, Gandhi T, Fu C, Jiang W, Xia G, Lingappan K, Coarfa C, Moorthy B

doi: 10.1016/j.redox.2023.102790

Published online 2023 Jun 16.

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Loss of growth differentiation factor 15 exacerbates lung injury in neonatal mice.

Al-Mudares F, Cantu Gutierrez M, Cantu A, Jiang W, Wang L, Dong X, Moorthy B, Sajti E, Lingappan K

doi: 10.1152/ajplung.00086.2023

Published online 2023 Jun 27.

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Endothelial to mesenchymal transition in neonatal hyperoxic lung injury: role of sex as a biological variable.

Cantu A, Cantu Gutierrez M, Zhang Y, Dong X, Lingappan K

doi: 10.1152/physiolgenomics.00037.2023

Published online 2023 Jul 3.

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Loss of microRNA-30a and sex-specific effects on the neonatal hyperoxic lung injury.

Grimm SL, Reddick S, Dong X, Leek C, Wang AX, Gutierrez MC, Hartig SM, Moorthy B, Coarfa C, Lingappan K

doi: 10.1186/s13293-023-00535-6

Published online 2023 Aug 8.

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Molecular insights using spatial transcriptomics of the distal lung in congenital diaphragmatic hernia.

Lingappan K, Olutoye OO 2nd, Cantu A, Cantu Gutierrez ME, Cortes-Santiago N, Hammond JD, Gilley J, Quintero JR, Li H, Polverino F, Gleghorn JP, Keswani SG

doi: 10.1152/ajplung.00154.2023

Published online 2023 Aug 22.

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Modulation of Recovery from Neonatal Hyperoxic Lung Injury by Sex as a Biological Variable.

Cantu A, Gutierrez MC, Dong X, Leek C, Anguera M, Lingappan K

pii: 2023.08.09.552532. doi: 10.1101/2023.08.09.552532

Published online 2023 Aug 13.

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Pharmacotherapy of BPD: Current status & future perspectives.

Ryan RM, Mukherjee D, Ford S, Lingappan K

doi: 10.1016/j.semperi.2023.151819

Published online 2023 Sep 9.

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Toolkit for gender equity in pediatrics.

Machut KZ, Lingappan K, Savich R, Dammann CEL

doi: 10.1038/s41390-023-02846-1

Published online 2023 Oct 13.

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"Exploring the Association of Male Sex with Adverse Outcomes in Severe Bronchopulmonary Dysplasia: A Retrospective, Multi-Center Cohort Study".

Hammond JD 2nd, Kielt MJ, Conroy S, Lingappan K, Austin ED, Eldredge LC, Truog WE, Abman SH, Nelin LD, Cuevas Guaman M

pii: S0012-3692(23)05665-9. doi: 10.1016/j.chest.2023.10.020

Published online 2023 Oct 23.

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2022

Remarkable sex-specific differences at Single-Cell Resolution in Neonatal Hyperoxic Lung Injury.

Cantu A, Gutierrez MC, Dong X, Leek C, Sajti E, Lingappan K

doi: 10.1152/ajplung.00269.2022

Published online 2022 Oct 25.

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Growth and differentiation factor 15 (GDF15) levels predict adverse respiratory outcomes in premature neonates.

Almudares F, Hagan J, Chen X, Devaraj S, Moorthy B, Lingappan K

doi: 10.1002/ppul.26197

Published online 2022 Oct 7.

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Correction to: Call to action: gender equity in neonatology.

Machut KZ, Bhombal S, Escobedo M, Kataria-Hale J, Kushnir A, Lingappan K, Oji-Mmuo CN, Owens L, Savich R, Song C, Wright R, Dammann CEL

doi: 10.1038/s41372-022-01511-5

Published online 2022 Oct 4.

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The Cellular and Molecular Effects of Fetoscopic Endoluminal Tracheal Occlusion in Congenital Diaphragmatic Hernia.

Olutoye Ii OO, Short WD, Gilley J, Hammond Ii JD, Belfort MA, Lee TC, King A, Espinoza J, Joyeux L, Lingappan K, Gleghorn JP, Keswani SG

doi: 10.3389/fped.2022.925106

Published online 2022 Jul 5.

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Call to action: gender equity in neonatology.

Machut KZ, Bhombal S, Escobedo M, Kataria-Hale J, Kushnir A, Lingappan K, Oji-Mmuo CN, Owens L, Savich R, Song C, Wright R, Dammann CEL

doi: 10.1038/s41372-022-01390-w

Published online 2022 Apr 11.

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Correction to: Newborn Mice Lacking the Gene for Cyp1a1 Are More Susceptible to Oxygen-Mediated Lung Injury, and Are Rescued by Postnatal β-Naphthoflavone Administration: Implications for Bronchopulmonary Dysplasia in Premature Infants.

Maturu P, Wei-Liang Y, Jiang W, Wang L, Lingappan K, Barrios R, Liang Y, Moorthy B, Couroucli XI

doi: 10.1093/toxsci/kfac031

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Vision 2020: How Caregiving and Work Productivity Outlook Shifted for Academic Pediatric Faculty.

Chumpitazi CE, Camp EA, Cuevas-Guaman M, Doughty C, Kancherla B, Lingappan K, Moran NE, Murray KO, Perez O, Shekerdemian LS, O'Connor TM

doi: 10.1089/jwh.2021.0555

Published online 2022 Feb 14.

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Effect of Coronavirus Disease-2019 on the Workload of Neonatologists.

Machut KZ, Kushnir A, Oji-Mmuo CN, Kataria-Hale J, Lingappan K, Kwon S, Dammann CEL

doi: 10.1016/j.jpeds.2021.11.002

Published online 2021 Nov 6.

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National professional society augments career development and leadership amongst neonatal fellows and early career neonatologists.

Koo J, Lingappan K, Song C

doi: 10.1038/s41372-021-01153-z

Published online 2021 Jul 22.

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2021

Role of Human NADPH Quinone Oxidoreductase (NQO1) in Oxygen-Mediated Cellular Injury and Oxidative DNA Damage in Human Pulmonary Cells.

Burke R, Chu C, Zhou GD, Putluri V, Putluri N, Stading RE, Couroucli X, Lingappan K, Moorthy B

doi: 10.1155/2021/5544600

Published online 2021 Oct 15.

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Effect of sex chromosomes versus hormones in neonatal lung injury.

Grimm SL, Dong X, Zhang Y, Carisey AF, Arnold AP, Moorthy B, Coarfa C, Lingappan K

pii: 146863. doi: 10.1172/jci.insight.146863

Published online 2021 Jul 8.

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Does the Epigenome Hold Clues to Leptin-associated Hypertension in Obesity?

Lingappan K

doi: 10.1165/rcmb.2021-0199ED

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Altered metabolic and inflammatory transcriptomics after cardiac surgery in neonates with congenital heart disease.

Jain PN, Robertson M, Lasa JJ, Shekerdemian L, Guffey D, Zhang Y, Lingappan K, Checchia P, Coarfa C

doi: 10.1038/s41598-021-83882-x

Published online 2021 Mar 2.

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The role of cytochrome P450 (CYP) enzymes in hyperoxic lung injury.

Stading R, Couroucli X, Lingappan K, Moorthy B

doi: 10.1080/17425255.2021.1853705

Published online 2020 Dec 13.

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2020

Role of Growth Differentiation Factor 15 in Lung Disease and Senescence: Potential Role Across the Lifespan.

Al-Mudares F, Reddick S, Ren J, Venkatesh A, Zhao C, Lingappan K

doi: 10.3389/fmed.2020.594137

Published online 2020 Dec 3.

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Molecular role of cytochrome P4501A enzymes inoxidative stress.

Stading R, Chu C, Couroucli X, Lingappan K, Moorthy B

doi: 10.1016/j.cotox.2020.07.001

Published online 2020 Jul 24.

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Epigenetic response to hyperoxia in the neonatal lung is sexually dimorphic.

Coarfa C, Grimm SL, Katz T, Zhang Y, Jangid RK, Walker CL, Moorthy B, Lingappan K

doi: 10.1016/j.redox.2020.101718

Published online 2020 Sep 11.

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Oxygen-mediated lung injury in mice lacking the gene for NRF2: Rescue with the cytochrome P4501A-inducer, beta-naphthoflavone (BNF), and differential sex-specific effects.

Callaway DA, Jiang W, Wang L, Lingappan K, Moorthy B

doi: 10.1016/j.freeradbiomed.2020.07.027

Published online 2020 Aug 10.

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Understanding the age divide in COVID-19: why are children overwhelmingly spared?

Lingappan K, Karmouty-Quintana H, Davies J, Akkanti B, Harting MT

doi: 10.1152/ajplung.00183.2020

Published online 2020 Jun 3.

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The Wnt Signaling Pathway and the Development of Bronchopulmonary Dysplasia.

Lingappan K, Savani RC

doi: 10.1164/rccm.202002-0277ED

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2019

Role of <i>HIF-1α-miR30a-Snai1</i> Axis in Neonatal Hyperoxic Lung Injury.

Zhang Y, Dong X, Lingappan K

doi: 10.1155/2019/8327486

Published online 2019 Oct 22.

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Impact of Early Life Antibiotic Exposure and Neonatal Hyperoxia on the Murine Microbiome and Lung Injury.

Althouse MH, Stewart C, Jiang W, Moorthy B, Lingappan K

doi: 10.1038/s41598-019-51506-0

Published online 2019 Oct 18.

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Association between elevated placental polycyclic aromatic hydrocarbons (PAHs) and PAH-DNA adducts from Superfund sites in Harris County, and increased risk of preterm birth (PTB).

Suter MA, Aagaard KM, Coarfa C, Robertson M, Zhou G, Jackson BP, Thompson D, Putluri V, Putluri N, Hagan J, Wang L, Jiang W, Lingappan K, Moorthy B

doi: 10.1016/j.bbrc.2019.06.049

Published online 2019 Jun 14.

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MicroRNA-30a as a candidate underlying sex-specific differences in neonatal hyperoxic lung injury: implications for BPD.

Zhang Y, Coarfa C, Dong X, Jiang W, Hayward-Piatkovskyi B, Gleghorn JP, Lingappan K

doi: 10.1152/ajplung.00372.2018

Published online 2018 Nov 1.

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2018

Sex-specific differences in primary neonatal murine lung fibroblasts exposed to hyperoxia in vitro: implications for bronchopulmonary dysplasia.

Balaji S, Dong X, Li H, Zhang Y, Steen E, Lingappan K

doi: 10.1152/physiolgenomics.00075.2018

Published online 2018 Aug 31.

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Pulmonary endothelial cells exhibit sexual dimorphism in their response to hyperoxia.

Zhang Y, Dong X, Shirazi J, Gleghorn JP, Lingappan K

doi: 10.1152/ajpheart.00416.2018

Published online 2018 Aug 10.

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Mice Lacking the Cytochrome P450 1B1 Gene Are Less Susceptible to Hyperoxic Lung Injury Than Wild Type.

Veith AC, Bou Aram B, Jiang W, Wang L, Zhou G, Jefcoate CR, Couroucli XI, Lingappan K, Moorthy B

doi: 10.1093/toxsci/kfy154

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Videolaryngoscopy versus direct laryngoscopy for tracheal intubation in neonates.

Lingappan K, Arnold JL, Fernandes CJ, Pammi M

doi: 10.1002/14651858.CD009975.pub3

Published online 2018 Jun 4.

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NF-κB in Oxidative Stress.

Lingappan K

doi: 10.1016/j.cotox.2017.11.002

Published online 2017 Nov 7.

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Noninvasive ventilation strategies: which to choose?

Thomas AN, Hagan JL, Lingappan K

doi: 10.1038/s41372-017-0026-2

Published online 2017 Dec 27.

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β-Naphthoflavone treatment attenuates neonatal hyperoxic lung injury in wild type and Cyp1a2-knockout mice.

Lingappan K, Maturu P, Liang YW, Jiang W, Wang L, Moorthy B, Couroucli XI

doi: 10.1016/j.taap.2017.11.017

Published online 2017 Nov 26.

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Hyperoxia-mediated transcriptional activation of cytochrome P4501A1 (CYP1A1) and decreased susceptibility to oxygen-mediated lung injury in newborn mice.

Jiang W, Maturu P, Liang YW, Wang L, Lingappan K, Couroucli X

doi: 10.1016/j.bbrc.2017.10.166

Published online 2017 Oct 31.

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2017

Focused Evidence-Based Medicine Curriculum for Trainees in Neonatal-Perinatal Medicine.

Pammi M, Lingappan K, Carbajal MM, Suresh GK

doi: 10.15766/mep_2374-8265.10664

Published online 2017 Dec 26.

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Sexual dimorphism of the pulmonary transcriptome in neonatal hyperoxic lung injury: identification of angiogenesis as a key pathway.

Coarfa C, Zhang Y, Maity S, Perera DN, Jiang W, Wang L, Couroucli X, Moorthy B, Lingappan K

doi: 10.1152/ajplung.00230.2017

Published online 2017 Aug 17.

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Sex-specific differences in the modulation of Growth Differentiation Factor 15 (GDF15) by hyperoxia in vivo and in vitro: Role of Hif-1α.

Zhang Y, Jiang W, Wang L, Lingappan K

doi: 10.1016/j.taap.2017.07.016

Published online 2017 Jul 20.

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Mind the gap: can videolaryngoscopy bridge the competency gap in neonatal endotracheal intubation among pediatric trainees? a randomized controlled study.

Parmekar S, Arnold JL, Anselmo C, Pammi M, Hagan J, Fernandes CJ, Lingappan K

doi: 10.1038/jp.2017.72

Published online 2017 May 18.

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Role of Cytochrome P450 (CYP)1A in Hyperoxic Lung Injury: Analysis of the Transcriptome and Proteome.

Lingappan K, Maity S, Jiang W, Wang L, Couroucli X, Veith A, Zhou G, Coarfa C, Moorthy B

doi: 10.1038/s41598-017-00516-x

Published online 2017 Apr 4.

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Differential sex-specific effects of oxygen toxicity in human umbilical vein endothelial cells.

Zhang Y, Lingappan K

doi: 10.1016/j.bbrc.2017.03.058

Published online 2017 Mar 16.

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Newborn Mice Lacking the Gene for Cyp1a1 Are More Susceptible to Oxygen-Mediated Lung Injury, and Are Rescued by Postnatal β-Naphthoflavone Administration: Implications for Bronchopulmonary Dysplasia in Premature Infants.

Maturu P, Wei-Liang Y, Jiang W, Wang L, Lingappan K, Barrios R, Liang Y, Moorthy B, Couroucli XI

doi: 10.1093/toxsci/kfx036

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One-Month-Old Infant With Hypotonia and Cardiorespiratory Arrest.

Hoover J, Lingappan K

doi: 10.1177/0009922816656627

Published online 2016 Jul 20.

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2016

Sex-specific differences in neonatal hyperoxic lung injury.

Lingappan K, Jiang W, Wang L, Moorthy B

doi: 10.1152/ajplung.00047.2016

Published online 2016 Jun 24.

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Mechanistic role of cytochrome P450 (CYP)1B1 in oxygen-mediated toxicity in pulmonary cells: A novel target for prevention of hyperoxic lung injury.

Dinu D, Chu C, Veith A, Lingappan K, Couroucli X, Jefcoate CR, Sheibani N, Moorthy B

doi: 10.1016/j.bbrc.2016.05.125

Published online 2016 May 25.

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Relationship between PCO2 and unfavorable outcome in infants with moderate-to-severe hypoxic ischemic encephalopathy.

Lingappan K, Kaiser JR, Srinivasan C, Gunn AJ

doi: 10.1038/pr.2016.62

Published online 2016 Apr 6.

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2015

Can maternal DHA supplementation offer long-term protection against neonatal hyperoxic lung injury?

Lingappan K, Moorthy B

doi: 10.1152/ajplung.00313.2015

Published online 2015 Sep 11.

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Role of GDF15 (growth and differentiation factor 15) in pulmonary oxygen toxicity.

Tiwari KK, Moorthy B, Lingappan K

doi: 10.1016/j.tiv.2015.05.008

Published online 2015 May 21.

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Sex-specific differences in hyperoxic lung injury in mice: role of cytochrome P450 (CYP)1A.

Lingappan K, Jiang W, Wang L, Couroucli XI, Moorthy B

doi: 10.1016/j.tox.2015.01.019

Published online 2015 Feb 19.

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Videolaryngoscopy versus direct laryngoscopy for tracheal intubation in neonates.

Lingappan K, Arnold JL, Shaw TL, Fernandes CJ, Pammi M

doi: 10.1002/14651858.CD009975.pub2

Published online 2015 Feb 18.

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Disruption of cytochrome P4501A2 in mice leads to increased susceptibility to hyperoxic lung injury.

Wang L, Lingappan K, Jiang W, Couroucli XI, Welty SE, Shivanna B, Barrios R, Wang G, Firoze Khan M, Gonzalez FJ, Jackson Roberts L, Moorthy B

doi: 10.1016/j.freeradbiomed.2015.01.019

Published online 2015 Feb 10.

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2014

Analysis of the transcriptome in hyperoxic lung injury and sex-specific alterations in gene expression.

Lingappan K, Srinivasan C, Jiang W, Wang L, Couroucli XI, Moorthy B

doi: 10.1371/journal.pone.0101581

Published online 2014 Jul 8.

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Differential concentration-specific effects of caffeine on cell viability, oxidative stress, and cell cycle in pulmonary oxygen toxicity in vitro.

Tiwari KK, Chu C, Couroucli X, Moorthy B, Lingappan K

doi: 10.1016/j.bbrc.2014.06.132

Published online 2014 Jul 2.

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Mice deficient in the gene for cytochrome P450 (CYP)1A1 are more susceptible than wild-type to hyperoxic lung injury: evidence for protective role of CYP1A1 against oxidative stress.

Lingappan K, Jiang W, Wang L, Wang G, Couroucli XI, Shivanna B, Welty SE, Barrios R, Khan MF, Nebert DW, Roberts LJ, Moorthy B

doi: 10.1093/toxsci/kfu106

Published online 2014 Jun 3.

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Increased susceptibility to hyperoxic lung injury and alveolar simplification in newborn rats by prenatal administration of benzo[a]pyrene.

Thakur VS, Liang YW, Lingappan K, Jiang W, Wang L, Barrios R, Zhou G, Guntupalli B, Shivanna B, Maturu P, Welty SE, Moorthy B, Couroucli XI

doi: 10.1016/j.toxlet.2014.03.006

Published online 2014 Mar 19.

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2013

Lactoferrin and the newborn: current perspectives.

Lingappan K, Arunachalam A, Pammi M

doi: 10.1586/14787210.2013.811927

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Sex-specific differences in hyperoxic lung injury in mice: implications for acute and chronic lung disease in humans.

Lingappan K, Jiang W, Wang L, Couroucli XI, Barrios R, Moorthy B

doi: 10.1016/j.taap.2013.06.007

Published online 2013 Jun 21.

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2006

Whooping cough: the current scene.

Singh M, Lingappan K

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