Publications

Machut KZ

Kushnir A

Oji-Mmuo CN

Kataria-Hale J

Lingappan K

Kwon S

Dammann CEL

Effect of Coronavirus Disease-2019 on the Workload of Neonatologists. The Journal of pediatrics. Published online 2021 Nov 6. pii: S0022-3476(21)01067-2. doi: 10.1016/j.jpeds.2021.11.002

Burke R

Chu C

Zhou GD

Putluri V

Putluri N

Stading RE

Couroucli X

Lingappan K

Moorthy B

Role of Human NADPH Quinone Oxidoreductase (NQO1) in Oxygen-Mediated Cellular Injury and Oxidative DNA Damage in Human Pulmonary Cells. Oxidative medicine and cellular longevity. Published online 2021 Oct 15. doi: 10.1155/2021/5544600

Lingappan K

Does the Epigenome Hold Clues to Leptin-associated Hypertension in Obesity? American journal of respiratory cell and molecular biology. doi: 10.1165/rcmb.2021-0199ED

Koo J

Lingappan K

Song C

National professional society augments career development and leadership amongst neonatal fellows and early career neonatologists. Journal of perinatology : official journal of the California Perinatal Association. Published online 2021 Jul 22. doi: 10.1038/s41372-021-01153-z

Grimm SL

Dong X

Zhang Y

Carisey AF

Arnold AP

Moorthy B

Coarfa C

Lingappan K

Effect of sex chromosomes versus hormones in neonatal lung injury. JCI insight. Published online 2021 Jul 8. pii: 146863. doi: 10.1172/jci.insight.146863

Jain PN

Robertson M

Lasa JJ

Shekerdemian L

Guffey D

Zhang Y

Lingappan K

Checchia P

Coarfa C

Altered metabolic and inflammatory transcriptomics after cardiac surgery in neonates with congenital heart disease. Scientific reports. Published online 2021 Mar 2. doi: 10.1038/s41598-021-83882-x

Stading R

Couroucli X

Lingappan K

Moorthy B

The role of cytochrome P450 (CYP) enzymes in hyperoxic lung injury. Expert opinion on drug metabolism & toxicology. Published online 2020 Dec 13. doi: 10.1080/17425255.2021.1853705

Al-Mudares F

Reddick S

Ren J

Venkatesh A

Zhao C

Lingappan K

Role of Growth Differentiation Factor 15 in Lung Disease and Senescence: Potential Role Across the Lifespan. Frontiers in medicine. Published online 2020 Dec 3. doi: 10.3389/fmed.2020.594137

Callaway DA

Jiang W

Wang L

Lingappan K

Moorthy B

Oxygen-mediated lung injury in mice lacking the gene for NRF2: Rescue with the cytochrome P4501A-inducer, beta-naphthoflavone (BNF), and differential sex-specific effects. Free radical biology & medicine. Published online 2020 Aug 10. doi: 10.1016/j.freeradbiomed.2020.07.027

Coarfa C

Grimm SL

Katz T

Zhang Y

Jangid RK

Walker CL

Moorthy B

Lingappan K

Epigenetic response to hyperoxia in the neonatal lung is sexually dimorphic. Redox biology. Published online 2020 Sep 11. doi: 10.1016/j.redox.2020.101718

Lingappan K

Savani RC

The Wnt Signaling Pathway and the Development of Bronchopulmonary Dysplasia. American journal of respiratory and critical care medicine. doi: 10.1164/rccm.202002-0277ED

Stading R

Chu C

Couroucli X

Lingappan K

Moorthy B

Molecular role of cytochrome P4501A enzymes inoxidative stress. Current opinion in toxicology. Published online 2020 Jul 24. doi: 10.1016/j.cotox.2020.07.001

Zhang Y

Dong X

Lingappan K

Role of <i>HIF-1α-miR30a-Snai1</i> Axis in Neonatal Hyperoxic Lung Injury. Oxidative medicine and cellular longevity. Published online 2019 Oct 22. doi: 10.1155/2019/8327486

Althouse MH

Stewart C

Jiang W

Moorthy B

Lingappan K

Impact of Early Life Antibiotic Exposure and Neonatal Hyperoxia on the Murine Microbiome and Lung Injury. Scientific reports. Published online 2019 Oct 18. doi: 10.1038/s41598-019-51506-0

Suter MA

Aagaard KM

Coarfa C

Robertson M

Zhou G

Jackson BP

Thompson D

Putluri V

Putluri N

Hagan J

Wang L

Jiang W

Lingappan K

Moorthy B

Association between elevated placental polycyclic aromatic hydrocarbons (PAHs) and PAH-DNA adducts from Superfund sites in Harris County, and increased risk of preterm birth (PTB). Biochemical and biophysical research communications. Published online 2019 Jun 14. doi: 10.1016/j.bbrc.2019.06.049

Zhang Y

Coarfa C

Dong X

Jiang W

Hayward-Piatkovskyi B

Gleghorn JP

Lingappan K

MicroRNA-30a as a candidate underlying sex-specific differences in neonatal hyperoxic lung injury: implications for BPD. American journal of physiology. Lung cellular and molecular physiology. Published online 2018 Nov 1. doi: 10.1152/ajplung.00372.2018

Zhang Y

Dong X

Shirazi J

Gleghorn JP

Lingappan K

Pulmonary endothelial cells exhibit sexual dimorphism in their response to hyperoxia. American journal of physiology. Heart and circulatory physiology. Published online 2018 Aug 10. doi: 10.1152/ajpheart.00416.2018

Balaji S

Dong X

Li H

Zhang Y

Steen E

Lingappan K

Sex-specific differences in primary neonatal murine lung fibroblasts exposed to hyperoxia in vitro: implications for bronchopulmonary dysplasia. Physiological genomics. Published online 2018 Aug 31. doi: 10.1152/physiolgenomics.00075.2018

Veith AC

Bou Aram B

Jiang W

Wang L

Zhou G

Jefcoate CR

Couroucli XI

Lingappan K

Moorthy B

Mice Lacking the Cytochrome P450 1B1 Gene Are Less Susceptible to Hyperoxic Lung Injury Than Wild Type. Toxicological sciences : an official journal of the Society of Toxicology. doi: 10.1093/toxsci/kfy154

Lingappan K

Arnold JL

Fernandes CJ

Pammi M

Videolaryngoscopy versus direct laryngoscopy for tracheal intubation in neonates. The Cochrane database of systematic reviews. Published online 2018 Jun 4. doi: 10.1002/14651858.CD009975.pub3

Thomas AN

Hagan JL

Lingappan K

Noninvasive ventilation strategies: which to choose? Journal of perinatology : official journal of the California Perinatal Association. Published online 2017 Dec 27. doi: 10.1038/s41372-017-0026-2

Lingappan K

NF-κB in Oxidative Stress. Current opinion in toxicology. Published online 2017 Nov 7. doi: 10.1016/j.cotox.2017.11.002

Lingappan K

Maturu P

Liang YW

Jiang W

Wang L

Moorthy B

Couroucli XI

β-Naphthoflavone treatment attenuates neonatal hyperoxic lung injury in wild type and Cyp1a2-knockout mice. Toxicology and applied pharmacology. Published online 2017 Nov 26. doi: 10.1016/j.taap.2017.11.017

Jiang W

Maturu P

Liang YW

Wang L

Lingappan K

Couroucli X

Hyperoxia-mediated transcriptional activation of cytochrome P4501A1 (CYP1A1) and decreased susceptibility to oxygen-mediated lung injury in newborn mice. Biochemical and biophysical research communications. Published online 2017 Oct 31. doi: 10.1016/j.bbrc.2017.10.166

Pammi M

Lingappan K

Carbajal MM

Suresh GK

Focused Evidence-Based Medicine Curriculum for Trainees in Neonatal-Perinatal Medicine. MedEdPORTAL : the journal of teaching and learning resources. Published online 2017 Dec 26. doi: 10.15766/mep_2374-8265.10664

Coarfa C

Zhang Y

Maity S

Perera DN

Jiang W

Wang L

Couroucli X

Moorthy B

Lingappan K

Sexual dimorphism of the pulmonary transcriptome in neonatal hyperoxic lung injury: identification of angiogenesis as a key pathway. American journal of physiology. Lung cellular and molecular physiology. Published online 2017 Aug 17. doi: 10.1152/ajplung.00230.2017

Zhang Y

Jiang W

Wang L

Lingappan K

Sex-specific differences in the modulation of Growth Differentiation Factor 15 (GDF15) by hyperoxia in vivo and in vitro: Role of Hif-1α. Toxicology and applied pharmacology. Published online 2017 Jul 20. doi: 10.1016/j.taap.2017.07.016

Maturu P

Wei-Liang Y

Jiang W

Wang L

Lingappan K

Barrios R

Liang Y

Moorthy B

Couroucli XI

Newborn Mice Lacking the Gene for Cyp1a1 Are More Susceptible to Oxygen-Mediated Lung Injury, and Are Rescued by Postnatal β-Naphthoflavone Administration: Implications for Bronchopulmonary Dysplasia in Premature Infants. Toxicological sciences : an official journal of the Society of Toxicology. doi: 10.1093/toxsci/kfx036

Zhang Y

Lingappan K

Differential sex-specific effects of oxygen toxicity in human umbilical vein endothelial cells. Biochemical and biophysical research communications. Published online 2017 Mar 16. doi: 10.1016/j.bbrc.2017.03.058

Lingappan K

Maity S

Jiang W

Wang L

Couroucli X

Veith A

Zhou G

Coarfa C

Moorthy B

Role of Cytochrome P450 (CYP)1A in Hyperoxic Lung Injury: Analysis of the Transcriptome and Proteome. Scientific reports. Published online 2017 Apr 4. doi: 10.1038/s41598-017-00516-x

Hoover J

Lingappan K

One-Month-Old Infant With Hypotonia and Cardiorespiratory Arrest. Clinical pediatrics. Published online 2016 Jul 20. doi: 10.1177/0009922816656627

Dinu D

Chu C

Veith A

Lingappan K

Couroucli X

Jefcoate CR

Sheibani N

Moorthy B

Mechanistic role of cytochrome P450 (CYP)1B1 in oxygen-mediated toxicity in pulmonary cells: A novel target for prevention of hyperoxic lung injury. Biochemical and biophysical research communications. Published online 2016 May 25. doi: 10.1016/j.bbrc.2016.05.125

Lingappan K

Jiang W

Wang L

Moorthy B

Sex-specific differences in neonatal hyperoxic lung injury. American journal of physiology. Lung cellular and molecular physiology. Published online 2016 Jun 24. doi: 10.1152/ajplung.00047.2016

Lingappan K

Kaiser JR

Srinivasan C

Gunn AJ

Relationship between PCO2 and unfavorable outcome in infants with moderate-to-severe hypoxic ischemic encephalopathy. Pediatric research. Published online 2016 Apr 6. doi: 10.1038/pr.2016.62

Lingappan K

Moorthy B

Can maternal DHA supplementation offer long-term protection against neonatal hyperoxic lung injury? American journal of physiology. Lung cellular and molecular physiology. Published online 2015 Sep 11. doi: 10.1152/ajplung.00313.2015

Tiwari KK

Moorthy B

Lingappan K

Role of GDF15 (growth and differentiation factor 15) in pulmonary oxygen toxicity. Toxicology in vitro : an international journal published in association with BIBRA. Published online 2015 May 21. doi: 10.1016/j.tiv.2015.05.008

Lingappan K

Jiang W

Wang L

Couroucli XI

Moorthy B

Sex-specific differences in hyperoxic lung injury in mice: role of cytochrome P450 (CYP)1A. Toxicology. Published online 2015 Feb 19. doi: 10.1016/j.tox.2015.01.019

Wang L

Lingappan K

Jiang W

Couroucli XI

Welty SE

Shivanna B

Barrios R

Wang G

Firoze Khan M

Gonzalez FJ

Jackson Roberts L

Moorthy B

Disruption of cytochrome P4501A2 in mice leads to increased susceptibility to hyperoxic lung injury. Free radical biology & medicine. Published online 2015 Feb 10. doi: 10.1016/j.freeradbiomed.2015.01.019

Lingappan K

Arnold JL

Shaw TL

Fernandes CJ

Pammi M

Videolaryngoscopy versus direct laryngoscopy for tracheal intubation in neonates. The Cochrane database of systematic reviews. Published online 2015 Feb 18. doi: 10.1002/14651858.CD009975.pub2

Thakur VS

Liang YW

Lingappan K

Jiang W

Wang L

Barrios R

Zhou G

Guntupalli B

Shivanna B

Maturu P

Welty SE

Moorthy B

Couroucli XI

Increased susceptibility to hyperoxic lung injury and alveolar simplification in newborn rats by prenatal administration of benzo[a]pyrene. Toxicology letters. Published online 2014 Mar 19. doi: 10.1016/j.toxlet.2014.03.006

Lingappan K

Jiang W

Wang L

Wang G

Couroucli XI

Shivanna B

Welty SE

Barrios R

Khan MF

Nebert DW

Roberts LJ

Moorthy B

Mice deficient in the gene for cytochrome P450 (CYP)1A1 are more susceptible than wild-type to hyperoxic lung injury: evidence for protective role of CYP1A1 against oxidative stress. Toxicological sciences : an official journal of the Society of Toxicology. Published online 2014 Jun 3. doi: 10.1093/toxsci/kfu106

Tiwari KK

Chu C

Couroucli X

Moorthy B

Lingappan K

Differential concentration-specific effects of caffeine on cell viability, oxidative stress, and cell cycle in pulmonary oxygen toxicity in vitro. Biochemical and biophysical research communications. Published online 2014 Jul 2. doi: 10.1016/j.bbrc.2014.06.132

Lingappan K

Srinivasan C

Jiang W

Wang L

Couroucli XI

Moorthy B

Analysis of the transcriptome in hyperoxic lung injury and sex-specific alterations in gene expression. PloS one. Published online 2014 Jul 8. doi: 10.1371/journal.pone.0101581

Lingappan K

Jiang W

Wang L

Couroucli XI

Barrios R

Moorthy B

Sex-specific differences in hyperoxic lung injury in mice: implications for acute and chronic lung disease in humans. Toxicology and applied pharmacology. Published online 2013 Jun 21. doi: 10.1016/j.taap.2013.06.007

Lingappan K

Arunachalam A

Pammi M

Lactoferrin and the newborn: current perspectives. Expert review of anti-infective therapy. doi: 10.1586/14787210.2013.811927

Singh M

Lingappan K

Whooping cough: the current scene. Chest.