Publications

Remarkable sex-specific differences at Single-Cell Resolution in Neonatal Hyperoxic Lung Injury.

Cantu A, Gutierrez MC, Dong X, Leek C, Sajti E, Lingappan K

American journal of physiology. Lung cellular and molecular physiology.

doi: 10.1152/ajplung.00269.2022

Published online 2022 Oct 25.

Growth and differentiation factor 15 (GDF15) levels predict adverse respiratory outcomes in premature neonates.

Almudares F, Hagan J, Chen X, Devaraj S, Moorthy B, Lingappan K

Pediatric pulmonology.

doi: 10.1002/ppul.26197

Published online 2022 Oct 7.

Correction to: Call to action: gender equity in neonatology.

Machut KZ, Bhombal S, Escobedo M, Kataria-Hale J, Kushnir A, Lingappan K, Oji-Mmuo CN, Owens L, Savich R, Song C, Wright R, Dammann CEL

Journal of perinatology : official journal of the California Perinatal Association.

doi: 10.1038/s41372-022-01511-5

Published online 2022 Oct 4.

The Cellular and Molecular Effects of Fetoscopic Endoluminal Tracheal Occlusion in Congenital Diaphragmatic Hernia.

Olutoye Ii OO, Short WD, Gilley J, Hammond Ii JD, Belfort MA, Lee TC, King A, Espinoza J, Joyeux L, Lingappan K, Gleghorn JP, Keswani SG

Frontiers in pediatrics.

doi: 10.3389/fped.2022.925106

Published online 2022 Jul 5.

Call to action: gender equity in neonatology.

Machut KZ, Bhombal S, Escobedo M, Kataria-Hale J, Kushnir A, Lingappan K, Oji-Mmuo CN, Owens L, Savich R, Song C, Wright R, Dammann CEL

Journal of perinatology : official journal of the California Perinatal Association.

doi: 10.1038/s41372-022-01390-w

Published online 2022 Apr 11.

Correction to: Newborn Mice Lacking the Gene for Cyp1a1 Are More Susceptible to Oxygen-Mediated Lung Injury, and Are Rescued by Postnatal β-Naphthoflavone Administration: Implications for Bronchopulmonary Dysplasia in Premature Infants.

Maturu P, Wei-Liang Y, Jiang W, Wang L, Lingappan K, Barrios R, Liang Y, Moorthy B, Couroucli XI

Toxicological sciences : an official journal of the Society of Toxicology.

doi: 10.1093/toxsci/kfac031

Vision 2020: How Caregiving and Work Productivity Outlook Shifted for Academic Pediatric Faculty.

Chumpitazi CE, Camp EA, Cuevas-Guaman M, Doughty C, Kancherla B, Lingappan K, Moran NE, Murray KO, Perez O, Shekerdemian LS, O'Connor TM

Journal of women's health (2002).

doi: 10.1089/jwh.2021.0555

Published online 2022 Feb 14.

Effect of Coronavirus Disease-2019 on the Workload of Neonatologists.

Machut KZ, Kushnir A, Oji-Mmuo CN, Kataria-Hale J, Lingappan K, Kwon S, Dammann CEL

The Journal of pediatrics.

doi: 10.1016/j.jpeds.2021.11.002

Published online 2021 Nov 6.

Role of Human NADPH Quinone Oxidoreductase (NQO1) in Oxygen-Mediated Cellular Injury and Oxidative DNA Damage in Human Pulmonary Cells.

Burke R, Chu C, Zhou GD, Putluri V, Putluri N, Stading RE, Couroucli X, Lingappan K, Moorthy B

Oxidative medicine and cellular longevity.

doi: 10.1155/2021/5544600

Published online 2021 Oct 15.

National professional society augments career development and leadership amongst neonatal fellows and early career neonatologists.

Koo J, Lingappan K, Song C

Journal of perinatology : official journal of the California Perinatal Association.

doi: 10.1038/s41372-021-01153-z

Published online 2021 Jul 22.

Effect of sex chromosomes versus hormones in neonatal lung injury.

Grimm SL, Dong X, Zhang Y, Carisey AF, Arnold AP, Moorthy B, Coarfa C, Lingappan K

JCI insight.

pii: 146863. doi: 10.1172/jci.insight.146863

Published online 2021 Jul 8.

Does the Epigenome Hold Clues to Leptin-associated Hypertension in Obesity?

Lingappan K

American journal of respiratory cell and molecular biology.

doi: 10.1165/rcmb.2021-0199ED

Altered metabolic and inflammatory transcriptomics after cardiac surgery in neonates with congenital heart disease.

Jain PN, Robertson M, Lasa JJ, Shekerdemian L, Guffey D, Zhang Y, Lingappan K, Checchia P, Coarfa C

Scientific reports.

doi: 10.1038/s41598-021-83882-x

Published online 2021 Mar 2.

Role of Growth Differentiation Factor 15 in Lung Disease and Senescence: Potential Role Across the Lifespan.

Al-Mudares F, Reddick S, Ren J, Venkatesh A, Zhao C, Lingappan K

Frontiers in medicine.

doi: 10.3389/fmed.2020.594137

Published online 2020 Dec 3.

Molecular role of cytochrome P4501A enzymes inoxidative stress.

Stading R, Chu C, Couroucli X, Lingappan K, Moorthy B

Current opinion in toxicology.

doi: 10.1016/j.cotox.2020.07.001

Published online 2020 Jul 24.

The role of cytochrome P450 (CYP) enzymes in hyperoxic lung injury.

Stading R, Couroucli X, Lingappan K, Moorthy B

Expert opinion on drug metabolism & toxicology.

doi: 10.1080/17425255.2021.1853705

Published online 2020 Dec 13.

Epigenetic response to hyperoxia in the neonatal lung is sexually dimorphic.

Coarfa C, Grimm SL, Katz T, Zhang Y, Jangid RK, Walker CL, Moorthy B, Lingappan K

Redox biology.

doi: 10.1016/j.redox.2020.101718

Published online 2020 Sep 11.

Oxygen-mediated lung injury in mice lacking the gene for NRF2: Rescue with the cytochrome P4501A-inducer, beta-naphthoflavone (BNF), and differential sex-specific effects.

Callaway DA, Jiang W, Wang L, Lingappan K, Moorthy B

Free radical biology & medicine.

doi: 10.1016/j.freeradbiomed.2020.07.027

Published online 2020 Aug 10.

Understanding the age divide in COVID-19: why are children overwhelmingly spared?

Lingappan K, Karmouty-Quintana H, Davies J, Akkanti B, Harting MT

American journal of physiology. Lung cellular and molecular physiology.

doi: 10.1152/ajplung.00183.2020

Published online 2020 Jun 3.

The Wnt Signaling Pathway and the Development of Bronchopulmonary Dysplasia.

Lingappan K, Savani RC

American journal of respiratory and critical care medicine.

doi: 10.1164/rccm.202002-0277ED

Role of <i>HIF-1α-miR30a-Snai1</i> Axis in Neonatal Hyperoxic Lung Injury.

Zhang Y, Dong X, Lingappan K

Oxidative medicine and cellular longevity.

doi: 10.1155/2019/8327486

Published online 2019 Oct 22.

Impact of Early Life Antibiotic Exposure and Neonatal Hyperoxia on the Murine Microbiome and Lung Injury.

Althouse MH, Stewart C, Jiang W, Moorthy B, Lingappan K

Scientific reports.

doi: 10.1038/s41598-019-51506-0

Published online 2019 Oct 18.

Association between elevated placental polycyclic aromatic hydrocarbons (PAHs) and PAH-DNA adducts from Superfund sites in Harris County, and increased risk of preterm birth (PTB).

Suter MA, Aagaard KM, Coarfa C, Robertson M, Zhou G, Jackson BP, Thompson D, Putluri V, Putluri N, Hagan J, Wang L, Jiang W, Lingappan K, Moorthy B

Biochemical and biophysical research communications.

doi: 10.1016/j.bbrc.2019.06.049

Published online 2019 Jun 14.

MicroRNA-30a as a candidate underlying sex-specific differences in neonatal hyperoxic lung injury: implications for BPD.

Zhang Y, Coarfa C, Dong X, Jiang W, Hayward-Piatkovskyi B, Gleghorn JP, Lingappan K

American journal of physiology. Lung cellular and molecular physiology.

doi: 10.1152/ajplung.00372.2018

Published online 2018 Nov 1.

Sex-specific differences in primary neonatal murine lung fibroblasts exposed to hyperoxia in vitro: implications for bronchopulmonary dysplasia.

Balaji S, Dong X, Li H, Zhang Y, Steen E, Lingappan K

Physiological genomics.

doi: 10.1152/physiolgenomics.00075.2018

Published online 2018 Aug 31.

Pulmonary endothelial cells exhibit sexual dimorphism in their response to hyperoxia.

Zhang Y, Dong X, Shirazi J, Gleghorn JP, Lingappan K

American journal of physiology. Heart and circulatory physiology.

doi: 10.1152/ajpheart.00416.2018

Published online 2018 Aug 10.

Mice Lacking the Cytochrome P450 1B1 Gene Are Less Susceptible to Hyperoxic Lung Injury Than Wild Type.

Veith AC, Bou Aram B, Jiang W, Wang L, Zhou G, Jefcoate CR, Couroucli XI, Lingappan K, Moorthy B

Toxicological sciences : an official journal of the Society of Toxicology.

doi: 10.1093/toxsci/kfy154

Videolaryngoscopy versus direct laryngoscopy for tracheal intubation in neonates.

Lingappan K, Arnold JL, Fernandes CJ, Pammi M

The Cochrane database of systematic reviews.

doi: 10.1002/14651858.CD009975.pub3

Published online 2018 Jun 4.

NF-κB in Oxidative Stress.

Lingappan K

Current opinion in toxicology.

doi: 10.1016/j.cotox.2017.11.002

Published online 2017 Nov 7.

Noninvasive ventilation strategies: which to choose?

Thomas AN, Hagan JL, Lingappan K

Journal of perinatology : official journal of the California Perinatal Association.

doi: 10.1038/s41372-017-0026-2

Published online 2017 Dec 27.

Focused Evidence-Based Medicine Curriculum for Trainees in Neonatal-Perinatal Medicine.

Pammi M, Lingappan K, Carbajal MM, Suresh GK

MedEdPORTAL : the journal of teaching and learning resources.

doi: 10.15766/mep_2374-8265.10664

Published online 2017 Dec 26.

β-Naphthoflavone treatment attenuates neonatal hyperoxic lung injury in wild type and Cyp1a2-knockout mice.

Lingappan K, Maturu P, Liang YW, Jiang W, Wang L, Moorthy B, Couroucli XI

Toxicology and applied pharmacology.

doi: 10.1016/j.taap.2017.11.017

Published online 2017 Nov 26.

Hyperoxia-mediated transcriptional activation of cytochrome P4501A1 (CYP1A1) and decreased susceptibility to oxygen-mediated lung injury in newborn mice.

Jiang W, Maturu P, Liang YW, Wang L, Lingappan K, Couroucli X

Biochemical and biophysical research communications.

doi: 10.1016/j.bbrc.2017.10.166

Published online 2017 Oct 31.

Sexual dimorphism of the pulmonary transcriptome in neonatal hyperoxic lung injury: identification of angiogenesis as a key pathway.

Coarfa C, Zhang Y, Maity S, Perera DN, Jiang W, Wang L, Couroucli X, Moorthy B, Lingappan K

American journal of physiology. Lung cellular and molecular physiology.

doi: 10.1152/ajplung.00230.2017

Published online 2017 Aug 17.

Sex-specific differences in the modulation of Growth Differentiation Factor 15 (GDF15) by hyperoxia in vivo and in vitro: Role of Hif-1α.

Zhang Y, Jiang W, Wang L, Lingappan K

Toxicology and applied pharmacology.

doi: 10.1016/j.taap.2017.07.016

Published online 2017 Jul 20.

Mind the gap: can videolaryngoscopy bridge the competency gap in neonatal endotracheal intubation among pediatric trainees? a randomized controlled study.

Parmekar S, Arnold JL, Anselmo C, Pammi M, Hagan J, Fernandes CJ, Lingappan K

Journal of perinatology : official journal of the California Perinatal Association.

doi: 10.1038/jp.2017.72

Published online 2017 May 18.

Role of Cytochrome P450 (CYP)1A in Hyperoxic Lung Injury: Analysis of the Transcriptome and Proteome.

Lingappan K, Maity S, Jiang W, Wang L, Couroucli X, Veith A, Zhou G, Coarfa C, Moorthy B

Scientific reports.

doi: 10.1038/s41598-017-00516-x

Published online 2017 Apr 4.

Differential sex-specific effects of oxygen toxicity in human umbilical vein endothelial cells.

Zhang Y, Lingappan K

Biochemical and biophysical research communications.

doi: 10.1016/j.bbrc.2017.03.058

Published online 2017 Mar 16.

Newborn Mice Lacking the Gene for Cyp1a1 Are More Susceptible to Oxygen-Mediated Lung Injury, and Are Rescued by Postnatal β-Naphthoflavone Administration: Implications for Bronchopulmonary Dysplasia in Premature Infants.

Maturu P, Wei-Liang Y, Jiang W, Wang L, Lingappan K, Barrios R, Liang Y, Moorthy B, Couroucli XI

Toxicological sciences : an official journal of the Society of Toxicology.

doi: 10.1093/toxsci/kfx036

One-Month-Old Infant With Hypotonia and Cardiorespiratory Arrest.

Hoover J, Lingappan K

Clinical pediatrics.

doi: 10.1177/0009922816656627

Published online 2016 Jul 20.

Sex-specific differences in neonatal hyperoxic lung injury.

Lingappan K, Jiang W, Wang L, Moorthy B

American journal of physiology. Lung cellular and molecular physiology.

doi: 10.1152/ajplung.00047.2016

Published online 2016 Jun 24.

Mechanistic role of cytochrome P450 (CYP)1B1 in oxygen-mediated toxicity in pulmonary cells: A novel target for prevention of hyperoxic lung injury.

Dinu D, Chu C, Veith A, Lingappan K, Couroucli X, Jefcoate CR, Sheibani N, Moorthy B

Biochemical and biophysical research communications.

doi: 10.1016/j.bbrc.2016.05.125

Published online 2016 May 25.

Relationship between PCO2 and unfavorable outcome in infants with moderate-to-severe hypoxic ischemic encephalopathy.

Lingappan K, Kaiser JR, Srinivasan C, Gunn AJ

Pediatric research.

doi: 10.1038/pr.2016.62

Published online 2016 Apr 6.

Can maternal DHA supplementation offer long-term protection against neonatal hyperoxic lung injury?

Lingappan K, Moorthy B

American journal of physiology. Lung cellular and molecular physiology.

doi: 10.1152/ajplung.00313.2015

Published online 2015 Sep 11.

Role of GDF15 (growth and differentiation factor 15) in pulmonary oxygen toxicity.

Tiwari KK, Moorthy B, Lingappan K

Toxicology in vitro : an international journal published in association with BIBRA.

doi: 10.1016/j.tiv.2015.05.008

Published online 2015 May 21.

Sex-specific differences in hyperoxic lung injury in mice: role of cytochrome P450 (CYP)1A.

Lingappan K, Jiang W, Wang L, Couroucli XI, Moorthy B

Toxicology.

doi: 10.1016/j.tox.2015.01.019

Published online 2015 Feb 19.

Videolaryngoscopy versus direct laryngoscopy for tracheal intubation in neonates.

Lingappan K, Arnold JL, Shaw TL, Fernandes CJ, Pammi M

The Cochrane database of systematic reviews.

doi: 10.1002/14651858.CD009975.pub2

Published online 2015 Feb 18.

Disruption of cytochrome P4501A2 in mice leads to increased susceptibility to hyperoxic lung injury.

Wang L, Lingappan K, Jiang W, Couroucli XI, Welty SE, Shivanna B, Barrios R, Wang G, Firoze Khan M, Gonzalez FJ, Jackson Roberts L, Moorthy B

Free radical biology & medicine.

doi: 10.1016/j.freeradbiomed.2015.01.019

Published online 2015 Feb 10.

Analysis of the transcriptome in hyperoxic lung injury and sex-specific alterations in gene expression.

Lingappan K, Srinivasan C, Jiang W, Wang L, Couroucli XI, Moorthy B

PloS one.

doi: 10.1371/journal.pone.0101581

Published online 2014 Jul 8.

Differential concentration-specific effects of caffeine on cell viability, oxidative stress, and cell cycle in pulmonary oxygen toxicity in vitro.

Tiwari KK, Chu C, Couroucli X, Moorthy B, Lingappan K

Biochemical and biophysical research communications.

doi: 10.1016/j.bbrc.2014.06.132

Published online 2014 Jul 2.

Mice deficient in the gene for cytochrome P450 (CYP)1A1 are more susceptible than wild-type to hyperoxic lung injury: evidence for protective role of CYP1A1 against oxidative stress.

Lingappan K, Jiang W, Wang L, Wang G, Couroucli XI, Shivanna B, Welty SE, Barrios R, Khan MF, Nebert DW, Roberts LJ, Moorthy B

Toxicological sciences : an official journal of the Society of Toxicology.

doi: 10.1093/toxsci/kfu106

Published online 2014 Jun 3.

Increased susceptibility to hyperoxic lung injury and alveolar simplification in newborn rats by prenatal administration of benzo[a]pyrene.

Thakur VS, Liang YW, Lingappan K, Jiang W, Wang L, Barrios R, Zhou G, Guntupalli B, Shivanna B, Maturu P, Welty SE, Moorthy B, Couroucli XI

Toxicology letters.

doi: 10.1016/j.toxlet.2014.03.006

Published online 2014 Mar 19.

Lactoferrin and the newborn: current perspectives.

Lingappan K, Arunachalam A, Pammi M

Expert review of anti-infective therapy.

doi: 10.1586/14787210.2013.811927

Sex-specific differences in hyperoxic lung injury in mice: implications for acute and chronic lung disease in humans.

Lingappan K, Jiang W, Wang L, Couroucli XI, Barrios R, Moorthy B

Toxicology and applied pharmacology.

doi: 10.1016/j.taap.2013.06.007

Published online 2013 Jun 21.

Whooping cough: the current scene.

Singh M, Lingappan K

Chest.