In our lab, we are interested in looking into the mechanisms behind sex-specific differences in lung diseases as it pertains to Neonatology.

Lung Tissue
Krithika Lingappan

Krithika Lingappan, MD, PhD, MS

Our unique niche is to elucidate the mechanisms sex-specific differences in neonatal hyperoxic lung injury with the goal to develop individualized therapeutic options to decrease morbidity in preterm babies. Sex-specific differences exist in various forms of organ injury in adults and children. Neonatal outcomes for males are worse than females for many diseases, including bronchopulmonary dysplasia (BPD). Being a neonatologist, Dr. Lingappan's interest was in the field of neonatal lung injury and repair.

Open positions

We are looking for graduate students looking to push our research forward while learning vital skill sets for their all-round development as a scientist.

Critical Thinking

Problem Solver

Willing to learn (Growth Mindset)



Strong work ethic

Normoxia vs Hyperoxia
Sprouting Angiogenesis

Sprouting Angiogenesis in male and female human pulmonary microvascular endothelial cells.

Our research

Bronchopulmonary dysplasia (BPD), a debilitating lung disease with long-term consequences, is the most common morbidity in extremely premature neonates. Male babies have a higher incidence of BPD compared to females. We study how lung injury and repair is different between male and female neonates and elucidate the molecular mechanisms modulating these sex-specific differences.